Topical Spironolactone Gel for Treatment of Mild to Moderate Acne Vulgaris

Topical spironolactone may be effective for the treatment of patients with acne and increased sebum secretion. A study concluded that 5% spironolactone topical gel resulted in a decrease in total acne lesions in patients with acne vulgaris, while it had no significant efficacy on severity.

J Dermatolog Treat. 2012 Feb;23(1):21-5. Epub 2010 Oct 22.
Comparison of the efficacy of 5% topical spironolactone gel and placebo in the treatment of mild and moderate acne vulgaris: a randomized controlled trial.
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We can compound customized formulations which contain numerous medications to provide a synergistic effect for treatment of resistant acne.

Int J Dermatol 1995 Jun;34(6):434-7
Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris.
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J Dermatol 1996 Apr;23(4):243-6
Topical spironolactone reduces sebum secretion rates in young adults.
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